The Effect of Pare (Momordica Charantia) L. Ethanol Extract on The Formation of Cataracts in Wistar White Rats

Nur Rahayuningsih, Desi Agni Mutia, Tita Nofianti

Abstract


Cataract is a clouding of the lens of the eye that reduces the amount of light entering and results in impaired vision. Cataracts remain the leading cause of visual impairment and blindness worldwide. Bitter melon fruit contain flavonoids and polyphenols which have antioxidant activities. Thirty of 9 days age wistar rats was divided into six group. Normal and negative group were given 2 ml/200 g BW rats 1% of PGA orally. Positive control was given 0,0009 g/200 g BW rat of vitamin C. Test group 1, 2, and 3 (were given 0,025 g/200 g BW rats; 0,051 g/200 g BW rats; and 0,1 g/200 g BW rats bitter melon fruit ethanol extract orally, respectivelly). All of the group except Normal were inducted with 0,25 mg/200 g BW rats sodium selenit subcutaneously. Treatment was given until the rat open the eyes for the first time (± 18 days). Eyes were observed macroscopic and microscopically in all group. The ethanol extract of bitter melon (Momordica charantia L.) has preventive activity against the formation of cataracts. The negative control group and dose I included in stage IV, positive control included in stage I, dose II included in stage III and dose III included in stage II. The most effective dose which prevent the formation of eye cataracts was 0,1 g/200 g BW rats bitter melon fruit (Momordica charantia L.) ethanol extract.

Keywords : Cataract, Bitter melon fruit, flavonoids

Full Text:

PDF


DOI: https://doi.org/10.37013/jf.v2i1.158

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Jurnal Farmasi (Journal of Pharmacy)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


IDENTITAS JURNAL

 
Nama Jurnal:Jurnal Farmasi (Journal of Pharmacy)
ISSN (cetak):2302-7436
ISSN (online):2656-8950
Penerbit:LPPM STIKES Nasional & Pengurus Cabang IAI Sukoharjo
Alamat:Jl. Raya Solo-Baki, Kwarasan, Grogol, Sukoharjo, Jawa Tengah 57552
Telepon:(0271)572339
Email:[email protected]
Tahun Pertama Terbit:2012