Identification of Drug Interactions on Prescribing Patients with Type 2 Diabetes Mellitus at Puskesmas X

khotimatul khusna

Abstract


Indonesia occupies the top ten countries with the highest population of people with Diabetes Mellitus in the world, which is ranked 5th with a range of 19.5 million people, and it is estimated that in 2045 it will increase to 28.6 million. Diabetes Mellitus is a chronic disease that is often accompanied by complications. This can lead to drug interactions. Drug interactions can affect the body's response to treatment. The purpose of this study was to determine the percentage of drug interactions on prescriptions received by patients with Type 2 Diabetes Mellitus at a health center in Surakarta. This research is a descriptive observational study. Data collection was carried out retrospectively through tracking records of drug use by patients with Diabetes Mellitus Type 2 at Puskesmas X. The sample in this study was all prescriptions for patients with Diabetes Mellitus Type 2 in April-December 2018. The results showed that the most prescribed antihyperglycemic drugs were 38, 89%, analgesics 16.20%, vitamins 14.2%, and antihypertensives 12.19%. The types of drugs that were most widely used in prescriptions were metformin at 18.98%, amlodipine at 11.57%, and paracetamol at 8.64%. The potential incidence of drug interactions is 62.5% of prescriptions. The conclusion of this study showed that the potential for pharmacokinetic drug interactions was 1.36%, the potential for pharmacodynamic drug interactions was 46.94%, and the incidence of unknown drug interactions was 51.70%.

Keywords


Interaction; Drug; Diabetes

Full Text:

PDF

References


American Diabetes Association. (2022). Standards of Medical Care in Diabetes 2022. The Journal of Clinical and Applied Research and Education, 45(January).

Anjarwati, D., Kusnadi, & Putri, A. R. (2013). Gambaran Penggunaan Obat Antidiabetik Oral di Puskesmas Slawi Kabupaten Tegal. Jurnal Farmasi Dan Ilmu Kesehatan, 09, 1–6.

Ayutthaya, S. S., & Adnan, N. (2020). Faktor Risiko Hipertensi pada Penderita Diabetes Mellitus Tipe 2. Jurnal Ilmu Kesehatan Masyarakat, 9(02), 60–71.

Dinas Kesehatan Provinsi Jawa Tengah. (2019). Profil Kesehatan Provinsi Jawa Tengah Tahun 2019 (Vol. 3511351, Issue 24). Dinas Kesehatan Provinsi Jawa Tengah.

Handayani, K., & Saibi, Y. (2019). Potensi Interaksi Obat Pada Resep Pasien Diabetes Melitus Rawat Jalan di RS X Jakarta Pusat.

Pharmaceutical and Biomedical Sciences Journal (PBSJ), 1(1), 43–47.

Ikatan Dokter Indonesia. (2016). Penataan Sistem Pelayanan Kesehatan Rujukan. In Ikatan Dokter Indonesia.

International Diabetes Federation. (2021). IDF Diabetes Atlas (10th ed.). International Diabetes Federation. www.diabetesatlas.org

Kementerian Kesehatan Republik Indonesia. (2019). Laporan Nasional Riskesdas 2018. In F1000Research (Vol. 10). Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.

Lira, C. P., Lolo, W. A., & Wewengkang, D. S. (2017). Potensi Drug Related Problems (DRPS) Penggunaan Obat Antidiabetes Pada Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Inap Rumah Sakit Kalooran Gmim Amurang. PHARMACON Jurnal Ilmiah Farmasi, 6(4), 241–248.

Medscape. (2022). Drug Interaction Checker.

https://reference.medscape.com/druginteractionchecker

Murtini, Oktianti, D., & Karminingtyas, S. R. (2020). Evaluasi Ketepatan Dosis Antihipertensi Pada Pasien Diabetes Mellitus Tipe 2 Di Puskesmas Demak 1 Kabupaten Demak. Universitas Ngudi Waluyo.

Murwati, I. S., & Murtisiwi, L. (2021). Identifikasi Potensi Interaksi Obat pada Peresepan Pasien Rawat Jalan Diabetes Melitus Tipe 2 dengan Hipertensi di RSUD dr. Soediran Mangun Sumarso Wonogiri. Jurnal Farmasi (Journal of Pharmacy), 10(1), 38–45.

Refdanita, & Rachmadi, E. . (2012). Potensi Interaksi Obat pada Pasien Diabetes Mellitus Tipe II Rawat Inap Rumah Sakit X Periode Januari-Juni 2012. Sainstech Farma, 8(2), 18–22.

Risal, A., Khusna, K., & Pambudi, R. S. (2021). Interaksi Obat Hipoglikemia Oral ( OHO ) dengan Obat Lain pada Pasien Diabetes Mellitus Tipe II berdasarkan Farmakokinetik dan Farmakodinamik di Puskesmas Sangkrah 1 st E-proceeding SENRIABDI 2021. E-Proceeding Senriabdi, 1(1), 979–990.

Sari, D. N. (2016). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Hipertensi dengan Komplikasi Diabetes Melitus dan Gagal Ginjal Kronik di Rumah Sakit “X” Tahun 2014. Universitas Muhammadiyah Surakarta.

Soelistijo, S. ., Suastika, K., Lindarto, D., Decroli, E., Permana, H., Sucipto, K. ., Kusnadi, Y., Budiman, Ikhsan, R., Sasiarini, L., Sanusi, H., Nugroho, H., & Susanto, H. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2021. PB PERKENI.

Suhailis, H, S., & H, N. U. (2021). Pola Penggunaan Obat Antidiabetes pada Pasien Diabetes Melitus Tipe2 Di Puskesmas Pegantenan. Archives Pharmacia, 3(1), 34.

Tambirang, R., Wiyono, W., & Mamarimbing, M. (2018). Evaluasi Penggunaan Dan Outcome Terapi Obat Antinyeri Pada Pasien Diabetik Neuropati Di Instalasi Rawat Inap RSUP Prof. Dr. R. D. Kandou Manado. Pharmacon, 7(3), 76–88.

Wijaya, I. N., Faturrohmah, A., Yuda, A., Giovani, S. T., Dina, K., Agustin, W. W., & Putri, H. P. N. . (2015). Profil Penggunaan Obat Pada Pasien Diabetes Melitus Di Puskesmas Wilayah Surabaya Timur. Jurnal Farmasi Komunitas, 2(1), 23–28.




DOI: https://doi.org/10.37013/jf.v11i2.209

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Jurnal Farmasi (Journal of Pharmacy)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


IDENTITAS JURNAL

 
Nama Jurnal:Jurnal Farmasi (Journal of Pharmacy)
ISSN (cetak):2302-7436
ISSN (online):2656-8950
Penerbit:LPPM STIKES Nasional & Pengurus Cabang IAI Sukoharjo
Alamat:Jl. Raya Solo-Baki, Kwarasan, Grogol, Sukoharjo, Jawa Tengah 57552
Telepon:(0271)572339
Email:[email protected]
Tahun Pertama Terbit:2012