Potensi Anti Hiperkolesterolemia Ekstrak Tumbuhan Sarang Semut (Myrmecodia Pendans Merr. & Perry)

Abstract

Hypercholesterolemia is one of the disturbances in blood lipid levels (dyslipidemia) in which blood cholesterol levels over 240 mg / dl. Hypercholesterolemia is one of the risk factors associated with the occurrence of coronary heart disease is a major cause and first of all deaths. The content of flavonoids in Sarang Semut (Myrmecodia pendens Merr. & Perry) has potential as anti-hypercholesterolemia drugs, because it can lower total cholesterol, Low Density Lipoprotein (LDL), and can prevent the oxidation of LDL. The purpose of this study was to determine the potential of sarang semut extracts in lowering cholesterol levels and levels of Low Density Lipoprotein (LDL), and triglyceride levels and increase HDL levels. The study was conducted by the research design Pre and Post Randomized Controlled Group Design uses animals try white rats (Rattus norvegicus) male, Wistar strain, with the inclusion criteria and have a healthy normal activity, aged about 12 -16 weeks with a weight of 200 grams ± as the research object. The study was conducted with six groups of rats that baseline group, negative control, positive control and and 3 treated with the extract at a dose of 400 mg / Kg BB, 600 mg /KgBB and 800 mg /Kg BB. The data analysis of total cholesterol, triglycerides, HDL and Low Density Lipoprotein (LDL) using one- way ANOVA test α = 0.05 by Tukey's test continuation.The results showed that the sarng semut extracts are qualitatively positive showed flavonoid compounds. Sarang semut extracts have potential as an anti hypercholesterolemia drugs to lower total cholesterol and increase HDL cholesterol levels significantly in a dose of 800 mg/KgBB. One way ANOVA test, sarang semut extract has a probability of 0.004 is smaller than 0.05. Test t test showed that the probability of 0.0046 <0.025. Sarang semut extracts can also reduce levels of triglycerides and LDL cholesterol in test animals but was not significantly different. Conclusions of this study are the ant nest plant extracts have potential as drug antihiperkolesterolemia lower total cholesterol and increase HDL cholesterol levels.