Efek Kemopreventif Ekstrak Metanol Kulit Kayu Nangka (Artocarpus heterophylla Lmk.) pada Karsinogenesis Kanker Payudara Tikus Betina yang Diinduksi DMBA

Abstrak

Chemopreventive compound discovery efforts that could inhibit and suppress the process need to be developed of carcinogenesis that is  cancer  prevention  strategies.  Jackfruit  (Artocarpus  heterophylla Lmk.) have been reported many chemical compounds that potent as anti-cancer properties. The aim of this research is to determine the potential anticarsinogenesis of  methanolic extract of jackfruit bark to suppress 7,12-Dimethylbenz(a) antrhacene (DMBA) induced breast cancer female development during the initiation phase and post initiation of cancer.

In this research 25 female Sprague-Dawley rats aged 47 days with 50-150 g body weight divided into 5 groups. Group I, II and III is a test group with extract dose of 200, 400 and 800 mg / kg BW. Group IV (comparison group) as a positive control (0.36 mg/200 g tamoxifen BB) and group V (the pain group) as a negative control (2 ml/200 g BB Na CMC 0.5%). DMBA (20 mg / kg) peroral given twice a week for five weeks. Extract and control treatment is given every day for 7 weeks with DMBA induction. Tumor development was examined by macroscopic and microscopic.

The results showed that the potential of methanolic extract of jackfruit bark to suppress breast cancer development is unknown because still necessary to optimize the induction of breast cancer carcinogenesis models.